{"id":7767,"date":"2024-03-01T14:44:17","date_gmt":"2024-03-01T21:44:17","guid":{"rendered":"https:\/\/www.breakthrought1d.org\/pacificnorthwest\/?p=7767"},"modified":"2025-12-01T17:29:11","modified_gmt":"2025-12-01T17:29:11","slug":"new-weight-loss-and-improved-glucose-management-study-at-rainier-clinical-research-center-for-people-living-with-t1d","status":"publish","type":"post","link":"https:\/\/www.breakthrought1d.org\/oregonsouthwestwa\/2024\/03\/01\/new-weight-loss-and-improved-glucose-management-study-at-rainier-clinical-research-center-for-people-living-with-t1d\/","title":{"rendered":"New Weight Loss and Improved Glucose Management Study at Rainier Clinical Research Center for People Living with T1D"},"content":{"rendered":"<p><strong>GLP-1 Agonists \u2013 Why All the Hype?<\/strong><\/p>\n<p>If you read the news or are on social media, you likely have heard at least a little about a class of medications, called GLP-1 agonists. GLP-1 stands for Glucagon-Like Peptide-1.\u00a0 GLP-1 agonists have received a lot of attention for their ability to cause weight loss, but their main use is to treat type 2 diabetes (T2D). Some examples of GLP-1 agonists you may have heard of are Semaglutide (Ozempic, Wegovy), Exenatide (Byetta), Dulaglutide (Trulicity), and Liraglutide (Victoza).<\/p>\n<p>In people with T2D, these medications effectively lower blood sugar levels, promote weight loss, and have additional benefits for heart health and kidney function.\u00a0 While GLP-1 agonists are only approved for people with T2D currently, researchers believe people with type 1 diabetes (T1D) may see similar benefits.<\/p>\n<p><strong>GLP-1 Agonists in Type 1 Diabetes<\/strong><\/p>\n<p>Although\u00a0GLP-1 agonists\u00a0are not yet approved for\u00a0the treatment of T1D, there is increased interest in exploring their use for glucose and weight control, as well as for their possible protective effects on the heart and kidney.\u00a0 Here\u2019s why they might be beneficial:<\/p>\n<ul>\n<li><strong>Weight management<\/strong>: GLP-1 agonists delay digestion, ensuring that nutrients from food are released gradually. This prevents rapid blood sugar spikes after meals. The slowed stomach transit time also leads to a feeling of fullness, causing people generally to eat less and thus lose weight.\u00a0 Weight gain is an issue for many people with T1D, particularly since insulin itself can cause weight gain.<\/li>\n<li><strong>Improved glucose control<\/strong>: In T2D, these drugs stimulate the body to produce more insulin. \u00a0Research suggests that these medications may lower\u00a0A1C levels\u00a0and enhance glucose regulation in T1D, as well.<\/li>\n<li><strong>Glucagon suppression<\/strong>: GLP-1 agonists inhibit glucagon secretion, thereby preventing excessive sugar release from the liver into the bloodstream.<\/li>\n<li><strong>Heart and kidney protection<\/strong>: Researchers think that the protective effects of GLP-1 agonists seen in patients with T2D may be seen similarly in patients with T1D. Given a lack of medications to treat these long-term complications in those living with T1D, this benefit would be very exciting.<\/li>\n<\/ul>\n<p><strong>GIP Agonists &#8211; What Do They Do?<\/strong><\/p>\n<p>GIP or Glucose-dependent Insulinotropic Polypeptide is another hormone that stimulates insulin release from the pancreas. There is an emerging class of drug that combines GLP-1 and GIP agonists in one medication. Similar to the expected benefit of GLP-1 agonists in treating people with T1D, researchers think that a combination of GLP-1\/GIP alongside insulin may provide improved glucose and weight control in T1D.<\/p>\n<p><strong>GLP-1\/GIP Clinical Trial Enrolling Now! <\/strong><\/p>\n<p>Currently, there is one GLP-1\/GIP medication FDA approved for glucose and weight control in diabetes: Tirzepatide (Mounjaro). Currently, Tirzepatide is only approved for T2D and is not yet approved for the treatment of T1D. However, other similar medications are being developed and investigated, including for the treatment of T1D.<\/p>\n<p>We are very fortunate that one of these <strong>new GLP-1\/GIP<\/strong> medications is being studied in a <strong>T1D clinical trial at Rainier Clinical Research Center<\/strong> in Seattle!\u00a0 Please consider enrolling in this trial, as we continue to push forward to increase glucose control, improve weight management, and reduce long-term complications of those living with T1D.<\/p>\n<p><u>Qualified Participants Must<\/u>:<br \/>\n\u2022 Be a generally healthy adult with no tobacco use<br \/>\n\u2022 Have A1C levels between 7%-10%<br \/>\n\u2022 Be using a CGM within 3 months<br \/>\n\u2022 Have a BMI \u2265 27 and not be using any weight loss supplements within 6 months<\/p>\n<p><em>Additional criteria apply<\/em><\/p>\n<p><u>Qualified Participants May<\/u>:<br \/>\n\u2022 Receive access to study professionals<br \/>\n\u2022 Receive up to $1800 compensation for time and travel<br \/>\n\u2022 Have access to study medications<\/p>\n<p>&nbsp;<\/p>\n<p><strong>If you are interested, you can find details <\/strong><a href=\"https:\/\/www.rainier-research.com\/current-studies?_ga=2.204996816.1128378621.1708981088-2129683442.1686588647#!\/study\/881\"><strong>here for the Carmot GLP-1\/GIP T1D Study<\/strong><\/a><\/p>\n<p><strong>You can also contact RCRC at:<\/strong><\/p>\n<p><strong>Phone<\/strong>: 1-425-251-1720<br \/>\n<strong>Email<\/strong>:\u00a0<a href=\"mailto:recruitment@rainier-research.com\"><strong>recruitment@rainier-research.com<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>GLP-1 Agonists \u2013 Why All the Hype? If you read the news or are on social media, you likely have heard at least a little about a class of medications, called GLP-1 agonists. GLP-1 stands for Glucagon-Like Peptide-1.\u00a0 GLP-1 agonists&hellip;<\/p>\n","protected":false},"author":1317,"featured_media":7261,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ep_exclude_from_search":false,"publish_on_app_meta":"True","iawp_total_views":3,"footnotes":"","_members_access_role":[],"_members_access_error":"","bt1d_storytelling_post":false,"bt1d_storytelling_more_posts":[]},"topics":[31],"class_list":["post-7767","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","jdrf_topic-clinical-trials"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Weight Loss and Improved Glucose Management Study at Rainier Clinical Research Center for People Living with T1D - Oregon and Southwest Washington Chapter<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Weight Loss and Improved Glucose Management Study at Rainier Clinical Research Center for People Living with T1D - Oregon and Southwest Washington Chapter\" \/>\n<meta property=\"og:description\" content=\"GLP-1 Agonists \u2013 Why All the Hype? 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