A meeting of the minds

This past week, Breakthrough T1D helped organize an event hosted by Member of European Parliament Tomislav Sokol, Ph.D., titled “Accelerating Breakthroughs to Address Unmet Needs in Type 1 Diabetes.” This meeting, a significant coming-together of Breakthrough T1D and European policymakers, focused on the role of the EU in addressing the needs of the T1D community and accelerating T1D breakthroughs.

The purpose of this meeting was to raise awareness of T1D and the urgent need for the accelerated development and approval of breakthrough therapies in the EU. Conversations between Breakthrough T1D and European policymakers homed in on barriers and opportunities to advancing cures—including cell therapies and disease-modifying therapies—in the EU to get them into the hands of people with T1D, faster. This was an important step in establishing an open dialogue between Breakthrough T1D and the EU Institutions about working together to address T1D globally.

“This event in the EU Parliament allows us to engage with important decision-makers to ensure that the research and policy environments are oriented in a way to accelerate development of T1D breakthrough therapies in the EU as we also do in other countries,” explained Campbell Hutton, Senior Vice President of Global Advocacy at Breakthrough T1D.

Attendees

Several Breakthrough T1D leadership and staff members attended the meeting, including Thomas Danne, M.D., Ph.D., Chief Medical Officer, Global; Sanjoy Dutta, Ph.D., Chief Scientific Officer; Lynn Starr, Chief Global Advocacy Officer, Carmen Hurtado del Pozo, Director, European Research; and Campbell Hutton, Senior Vice President of Global Advocacy.

Several Members of the European Parliament (MEP) in addition to host Tomislav Sokol, Ph.D., were in attendance. Other attendees included people with a lived experience of T1D, health staff from EU Member States, researchers in the EU, and other European diabetes organizations.

Dr. Dutta delivered a talk on the role of breakthrough therapies in transforming T1D. Dr. Danne moderated a panel to provide insight about unlocking the potential of cell therapies breakthroughs in the EU with T1D cell therapy researchers: Professor Lorenzo Piemonti, M.D., Director of the Diabetes Research Institute at Vita-Salute San Raffaele University and Associate Professor Francoise Carlotti, Ph.D., Head of the Islet Research Lab at Leiden University Medical Center. Finally, Lynn Starr closed with remarks about our shared global responsibility to work toward breakthrough T1D therapies.

Breakthrough T1D leadership and staff who attended the meeting.

When and where it took place

The event took place on June 5, 2025, in Brussels, Belgium, at the European Parliament.

Driving toward T1D cures in the EU and beyond

T1D is on the rise around the world, including in Europe. Recent publications by Breakthrough T1D staff and leadership brought attention to the rise in incidence and global T1D burden. We need to act now in conjunction with governments around the world—like the EU—to address the unmet needs of everyone around the world affected by T1D.

T1D cures, including cell therapies, are advancing through the clinical pipeline. Bringing awareness of T1D to the forefront—and educating key people on the progress we’re making toward cures—will be incredibly important for driving T1D research forward in the EU. This represents a critical opportunity for the EU to accelerate cell therapies faster than ever. As a global organization, Breakthrough T1D is collaborating with the EU government to help make this possible.

As the largest global funder of T1D research, Breakthrough T1D has provided funding to researchers across the world in addition to the EU. Right now, Breakthrough T1D is supporting €56 million in European initiatives, including 31 clinical trials—representing 19% of our funded research (including the U.K.). Breakthrough T1D has expert teams in research, medical, regulatory, and advocacy in Europe, meaning we are uniquely positioned to provide guidance on how the EU can strengthen its T1D efforts and collaborate on a global scale to drive T1D breakthroughs, especially in cell therapies.

Type 1 diabetes is a critical disease in Europe, and I was pleased to host an event for the T1D community and my colleagues in the European Parliament to learn about the unmet needs in T1D and how we can work together to accelerate breakthrough therapies in Europe to address those needs.”

Tomislav Sokol, Ph.D.

Member of the European Parliament

What Breakthrough T1D leadership is saying

Lynn Starr, Chief Global Advocacy Officer

“This meeting is critically important to bringing the unmet needs of the T1D community into the spotlight in the EU. Global advocacy for curative T1D research is essential to achieving Breakthrough T1D’s mission, and continued collaboration with EU policymakers will get us there faster.”

Lynn Starr

Chief Global Advocacy Officer

ADCES Sanjoy Dutta and Anastasia Albanese-O'Neill

“Cell therapies are accelerating through the clinical pipeline faster than ever. We need to act now on a global scale to ensure that people with T1D around the world can access these transformative therapies. This meeting is a significant step toward that goal.”

Sanjoy Dutta, Ph.D.

Chief Scientific Officer

Accelerating global action is paramount to our mission

Global problems require global solutions. This meeting served as a critical launching point for a continued partnership with the EU to fill gaps and address unmet needs for the T1D community. Building relationships and fostering long-term partnerships is critically important for reaching our common goal of bringing cures to people with T1D as soon as possible.

These important conversations between Breakthrough T1D and the EU government align with our Project ACT (Accelerate Cell Therapies) initiative to accelerate the development of cell therapies that do not require immunosuppression—for everyone with T1D in every country. In addition, through international Centers of Reference, Breakthrough T1D’s Medical Affairs team is developing expert clinical care centers that will be trained and ready to provide cell therapies to people with T1D once they become available. We are at the forefront of global action to prepare the world for curative cell therapies.

We are driving toward a future in which everyone with T1D—no matter where they are—has access to therapies, treatments, and care, bringing us closer to achieving our mission of a world without T1D. The more people we have working toward our mission, the faster we will get there.

Breakthrough T1D’s newest mission pillar, Medical Affairs, is bridging the gap between access to and adoption of T1D therapies. The establishment of this program is essential to Project ACT (Accelerate Cell Therapies): Breakthrough T1D’s initiative to accelerate the development of manufactured islet cell replacement therapies that do not require immunosuppression. The goal is to make sure that people with type 1 diabetes (T1D) can get these therapies as soon as they hit the market.

The field is moving quickly: people are becoming insulin-independent in cell therapy clinical trials. We are advancing towards the submission of the first-generation manufactured islet cell therapy that requires immunosuppression, Vertex’s zimislecel (VX-880). We are at a critical moment and need to act now to ensure that healthcare providers (HCPs) are ready to bring manufactured islet cell therapies into clinical settings.

Enter Medical Affairs

This is where Medical Affairs comes in. The team, led by Thomas Danne, M.D., Chief Medical Officer International, is working with the medical community to anticipate obstacles to getting manufactured islet therapies into clinics and find ways to overcome them now.

To accomplish this, Breakthrough T1D recently hosted two cell therapy workshops, convening multidisciplinary, international experts in islet cell transplantation to discuss a clinical roadmap for manufactured islet cell therapies—and how to ensure that clinical teams are in place and prepared to provide these therapies to people with T1D who qualify. By preparing now, we can get this first-generation therapy into the hands of people with T1D as soon as possible after regulatory approval.

The cell therapy workshops were hosted by Breakthrough T1D’s Thomas Danne, M.D., Chief Medical Officer International, and Anastasia Albanese-O’Neill, Ph.D., APRN, CDCES, Vice President of Medical Affairs.

Read on to learn more about the cell therapy workshops, the attendees, and what each accomplished.

Workshop #1: Who may benefit most from manufactured cell replacement therapies

Attendees

The first of the cell therapy workshops, held in late April, convened transplant surgeons, T1D clinicians and researchers, a member of Vertex’s leadership team, a member of Breakthrough T1D’s Participant Advisory Council to represent people with a lived experience of T1D, and Breakthrough T1D Vice President of Research Esther Latres, Ph.D.

The purpose of this workshop was to start developing a five-year roadmap to help guide the T1D care community to support the adoption of manufactured islet cell therapies in clinical care. The evidence-based recommendations will be vetted by a larger group of clinical experts, diabetes organizations, and people with lived experience with T1D to ensure there is broad agreement. The consensus document will ultimately be published to expand its reach.

This process will summarize the essential evidence that will help HCPs decide who may benefit the most from manufactured islet cell replacement therapies. These decisions will take into account the perspective of people with T1D and differences in age, hypoglycemia unawareness, or kidney health, to name a few. This can help HCPs better understand the benefits versus risks for manufactured cell therapies on a person-by-person basis—making sure that each clinical decision is made jointly to prioritize long-term health.

Workshop #2: Pilot workshop to develop international Centers of Reference for T1D cell therapy

Attendees

The second cell therapy workshop, held in early May, convened clinicians from various global medical institutions, including University of Minnesota Medical Center, University of Wisconsin Health Transplant Center, the Penn Rodebaugh Diabetes Center, University of Chicago Medicine, IRCCS Ospedale San Raffaele (Italy), Institute of Transplantation, Newcastle upon Tyne (United Kingdom), and University of Alberta (Edmonton, Alberta, Canada).

Additional attendees from Breakthrough T1D included CEO Aaron Kowalski, Ph.D., Vice President of Research Esther Latres, Ph.D., the Medical Affairs team, a volunteer, and a member of the Participant Advisory Council, who is a person living with T1D.

The objective of this workshop was to take the first step toward creating Centers of Reference for T1D manufactured cell therapies. “The initial purpose is to accelerate readiness of healthcare professionals to deliver manufactured islet cell therapies once they become available,” explained Dr. Danne. “…making such a treatment a success needs teamwork. Accredited Centers of Reference will not only deliver advanced T1D treatments but also serve as a training hub for professionals aspiring to become experts.”

This workshop focused on better understanding what potential Centers of Reference need to be successful. The attendees covered a range of topics: what an ideal T1D care team might look like, the education and training required for experts in T1D manufactured islet cell therapy, and career development for early-stage T1D professionals.

The goal is to prepare expert clinicians—who are already doing islet cell transplants—to bring manufactured islet cell therapies into clinical practice at their institutions and others, once they have regulatory approval. These centers will serve as a benchmark for best practices in T1D manufactured cell therapy, establishing a network of expert teams to make sure that everyone who can benefit from manufactured cell replacement therapy is given the opportunity to consider it.

What the experts are saying

“We need to build consensus and teamwork. When manufactured cell therapies exist, it’s going to take significant coordination between endocrinologists, transplant surgeons, and people with T1D to ensure as many people as possible are benefiting from these therapies.”

Jon Odorico, M.D.

Professor of Surgery and Director of Pancreas and Islet Transplantation at University of Wisconsin Health Transplant Center

“It’s going to be a significant problem if we have a cure but no one has access to it because no one can deliver it. We must work together—transplant surgeons, endocrinologists, researchers, everyone. It’s like building Cape Canaveral in anticipation of sending rockets into space.”

Peter Senior, MBBS, Ph.D.

Islet Transplant Endocrinologist, Professor in the Department of Medicine, and Director of the Alberta Diabetes Research Institute at the University of Alberta, Canada

This is just the beginning

Manufactured islet cell therapies are coming. We need teamwork to get these therapies into clinics so people with T1D don’t have to wait years to get them. This is why Breakthrough T1D is acting now: when the first manufactured islet cell therapy hits the market, multidisciplinary care teams around the world will be ready. These workshops—the first of many—will help accelerate the safe and effective integration of manufactured islet cell therapies into clinics.

“This way we will ensure that the medical community is ready to deliver manufactured cell therapies once they become more widely available.,” Dr. Danne said. Thanks to the hard work of the Medical Affairs team at Breakthrough T1D, this goal is in sight.

Breakthrough T1D strives to accelerate life-changing breakthroughs to cure, prevent, and better treat type 1 diabetes (T1D) and its complications. To accomplish these goals, we use a multi-pronged strategic approach, including conducting scientific studies and educating our community. In line with these goals, Breakthrough T1D recently published two peer-reviewed journal articles. One detailed burdensome unmet needs in the T1D community and identified key steps we can take to meet these needs. The other used real-world data to better understand American T1D demographics and predict changes in the next decade.

Let’s take a deeper dive into each.

Unmet needs of the T1D community: More work is needed

This article, titled “The Urgent Need for Breakthrough Therapies and a World Without Type 1 Diabetes”, was published as a commentary in Diabetes Therapy in early April 2025.

About the publication

This commentary reviews previously existing data across the T1D care spectrum to help demonstrate the magnitude and significance of the unmet needs faced by people living with T1D. This information is used to emphasize the urgency researchers, sponsors, and regulators must place on developing cures for T1D. The authors provide recommendations and actionable steps to overcome scientific, clinical, and regulatory challenges that will help meet these needs.

Daily life with T1D is still a challenge

To say that the daily routine of people living with T1D is hard would be an understatement.

Insulin injections and dosage calculations. Wearable tech maintenance. Carbohydrate counting. Mealtime and exercise tracking. Doctor’s appointments. Hypoglycemia, hyperglycemia, and diabetic ketoacidosis (DKA) avoidance. It requires constant attention: 24 hours a day, 7 days a week.

The truth of the matter is that T1D management is a burdensome, demanding, and highly intensive task. There are no breaks, vacations, or time off—even overnight, it requires management. These challenges remain, even with today’s advancements in technology and the emergence of novel therapies for T1D. Simply put, we need to do more for the T1D community, and we cannot settle for the status quo.

The bigger picture

The global burden of T1D

11
The average number of years of life lost for people with T1D globally.
21%
The percent decrease in mortality rate for people with T1D in the last 30 years globally, which is not distributed equally among everyone with T1D.

The challenge of day-to-day T1D management compounds into long-term negative outcomes for the T1D population. Despite improvements in mortality rate, the life expectancy of people with T1D is still shorter than those without T1D.

Keeping blood glucose in a normal range is extremely difficult, and people with T1D need to be acutely aware of their insulin doses to prevent highs (hyperglycemia) and lows (hypoglycemia). Prolonged hyperglycemia leads to heart, kidney, and eye damage. Hypoglycemia can be very dangerous and a source of distress and anxiety, especially if it occurs often and eventually without symptoms (termed “hypoglycemia unawareness”).

The impact of hypoglycemia

25-40%
Percent of people with T1D who experience hypoglycemia unawareness.
30%
Percent of adults with T1D who have a fear of hypoglycemia.

Current technologies cannot solve the problem of hypoglycemia or make people with T1D have perfect blood sugar levels. As a whole, these challenges represent a profound emotional and mental burden for people with T1D, often leading to diabetes distress and burnout—which itself can lead to worse glycemic control. People with T1D have a tougher time managing the ins and outs of daily life because of the extreme mental and physical load of having T1D.

A longer life on its own is not the goal: it’s longer lives without ever having to think about T1D.

Breakthrough T1D’s vision for the future…

Breakthrough T1D envisions a world where the burden of T1D no longer exists. A world where people don’t have to manage their diabetes—they don’t take insulin, don’t have blood sugar highs and lows, and don’t develop complications. Curing T1D is our north star.

…and how to make it a reality

To achieve these goals, we need widespread screening, innovative research and therapies, patient-centered clinical approaches, and evolved regulatory pathways. We need to adjust the T1D paradigm and move clinical testing along at a quicker pace.

The regulatory route for new therapies determines whether companies, which have the greatest ability perform research in a quick and efficient manner, will invest their time and money into innovative T1D therapies. They are more encouraged to do so if they see defined and reasonable pathways for new therapies to reach the market—especially if healthcare systems are in place that will allow these therapies to be adopted by healthcare professionals and used by the people who need them most.

It starts with the decision-makers, who weigh the benefits versus risks of a new therapy. These decisions need to have more input from people who have a lived experience with T1D and can better decide if the benefits outweigh the risks, especially given the tremendous daily burden of living it. Clinical testing should broaden to include more populations of people with T1D—not just those who have severe disease—because nearly everyone has the chance to benefit. As the authors state in the commentary:

The magnitude of benefits required to outweigh a product’s risks should be determined by people living with T1D and no one else.

To further optimize T1D clinical trials, Breakthrough T1D and other experts have pushed for the validation of C-peptide, a biomarker for the body’s insulin production, as a clinical trial endpoint. Compared to the currently used endpoints, C-peptide would provide easier assessments and shorter clinical timeframes, thereby making the process of T1D therapy development more streamlined—and bringing these data to decision-makers sooner.

Once better clinical endpoints are validated, more personal experiences are incorporated into clinical trials, and the regulatory path to market is clear, companies will be encouraged to invest in T1D research programs, thereby speeding up research, innovation, and progress along the clinical pipeline—getting life-changing therapies into the hands people with T1D faster than ever.

What comes next?

This publication will be shared broadly with regulators, legislators, payers, and the T1D research community to encourage research, innovation, and funding and advocate for quicker, more efficient clinical testing and regulatory pathways to approval.

I think the misperception that the therapies available today are good enough is one of the most insidious challenges to ushering in the era of T1D cures…Today’s therapies do not offer the freedom from diabetes that people living with the disease want…I believe when we fully appreciate the daily experiences of people living with T1D, and when we use these experiences to guide our research development and regulatory decisions, we will also then have clear pathways for new therapies that meet these needs.”

Stephen Karpen, PharmD

Senior Director of Regulatory Affairs at Breakthrough T1D

This is a call to action for everyone working in the T1D space. The overarching purpose is to foster awareness of these unmet needs and the urgency with which we must act as a community to address them—by working together and collaborating across the pipeline of T1D management.

Read on to learn more about the population of people living with T1D with these unmet needs.

T1D demographics: From today to 2033

This article, titled “We Are on the Verge of Breakthrough Cures for Type 1 Diabetes, but Who Are the 2 Million Americans Who Have It?”, was published in the Journal of Health Economics and Outcomes Research in November 2024.

About the study

The purpose of this study was to identify key T1D demographics in the United States and predict how these demographics will change over the next decade. Using healthcare insurance claim datasets, population growth projections, and existing literature, the authors modeled T1D demographic changes between 2024 and 2033.

This study was funded by Breakthrough T1D in collaboration with the T1D Index team so that these data can be incorporated into the Index. (Disclaimer: the T1D index uses multiple datasets and publications to predict the number of people living with T1D, which may explain discrepancies in Index estimates and predictions from this study).

Incidence

The number of new T1D diagnoses in a given time period.

Prevalence

The total number of people with T1D (new and existing diagnoses) in a given time period.

T1D stats: Now

2.07 million

Number of people in the U.S. living with T1D.

47

Average age of people living with T1D.

67%

Percent of people with T1D who are 20–64 years old.

19%

Percent of people with T1D who are over 65 years old.

47%

Percent of people with T1D who have commercial health insurance plans. Other coverage includes Medicare (30%) and Medicaid (15%).

T1D stats: 10 years from now

2.29 million

Number of people in the U.S. living with T1D (due to increase in T1D incidence and improved survival from devices).

49

Average age of people living with T1D.

33%

Percent increase in T1D population that aged 65 and older (mostly due to aging of the current T1D population).

38%

Percent increase in T1D population that is aged 10 and younger.

44%

Percent of people with T1D who have private/commercial health insurance plans. Other coverage includes Medicare (30%) and Medicaid (17.4%).

30%

Percent increase in T1D population who will use Medicaid.

What comes next?

Despite significant advances in T1D technology, therapies, and care management, the T1D population still faces a greater risk of complications and a higher mortality rate. Breakthrough T1D leadership will use key information from this study to inform future strategic research and advocacy efforts.

This data gives us an opportunity to quantify key information about our community to inform decision-makers…With better data specific to those with T1D, we can ensure that we’re advocating for solutions that not only expand access but also promote a better health care system for those with T1D.” 

Lynn Starr

Chief Global Advocacy Officer at Breakthrough T1D

These data will help inform elected officials and payers about how healthcare policies may ultimately affect the T1D community—ensuring that the policies in place are having the greatest impact they can. The next phase of the project will analyze key demographic information in the context of access to cell therapies.

The ultimate goal is to ensure that everyone with T1D has access to the therapies, technology, and care that works best for them. By understanding T1D population demographics, Breakthrough T1D can make the most informed decisions possible as we move toward our goal of a world without T1D. We call on regulators, legislators, payers, and T1D researchers to take urgent action to meet the unmet needs of the T1D community now and in the future.

Breakthrough T1D volunteer Matt Varey trains for his Canadian coast to coast bike ride fundrasier

This May, Matt Varey, a key volunteer with Breakthrough T1D since 2001, will embark on an ambitious two-month-long, 7,500-kilometer cycling journey across Canada.

As Matt rides Coast-to-Coast for Cures in support of Breakthrough T1D, his goal is that his passion and drive will inspire people to give generously to make each day better for those living with type 1 diabetes (T1D) while driving toward cures.

Matt has held a series of key volunteer roles within Breakthrough T1D. He currently serves on both the Breakthrough T1D International Board of Directors as Vice Chair and the Breakthrough T1D Canada Board of Directors

Matt sat down with Breakthrough T1D Canada to share more about his motivations behind taking on such an ambitious fundraiser and why supporting the T1D community is so important to him.

You’ve been involved with Breakthrough T1D as a volunteer and board member for over 20 years. How did you first get connected with the organization?

Matt Varey: My relationship with Breakthrough T1D (then JDRF) started in 2001.  My job at the Royal Bank of Canada (RBC) transferred me to Toronto. At that time, we were asked to build a new Canadian business within the bank, and it entailed me and other leaders going across Canada and speaking to employees very passionately and credibly about what they were going to help build.

Banking is a human business based on trust. I had to get out of my introverted shell and talk to employees, so I would ask them, “Who are you as a person? I want to get to know you as a human beyond just work.” I had no idea what Breakthrough T1D (then JDRF) was at the time. And you’d hear from people about their kids or sports, but one or two people would get teary or speak with a crack in their voice. So, naturally, I would probe a bit and ask more, and they would tell me about their family member and their journey with T1D.

So, when I got back from this Canada-wide work trip, I learned about the Breakthrough T1D “battle of the banks” Ride and thought to myself, “Wow, I have to do this.” That spring, I was part of the RBC Ride team. I saw all these people raising money for T1D research, and I made this connection to the people I met along that work trip affected by T1D, and I got the bug. My mother always said, “What’s given is yours forever,” and I knew I had a new purposeful journey with Breakthrough T1D.

It all flowed from there. I became the chair of the RBC Ride Cabinet and then the National Cabinet Chair. I saw the power of progress; I saw the dedication and the passion of people. I said, “I can’t stop at the Ride.” And then I met a fabulous mentor, one of the most important people in my life, Peter Oliver.

Peter was one of the founding fundraisers of what was then JDRF Canada because of his daughter Vanessa, who lives with T1D. He was such a giving person, and he taught me things I will never forget about giving back. He told me, “Always think big, never take no for an answer.”

Peter was the definition of a mentor, about what Breakthrough T1D stood for and the people who worked there. And he knew that he had this young guy named Matt who would follow anything he asked. I’ve been a Board Member, Vice Chair, and Chair of Breakthrough T1D Canada, and I’ve never felt a culture of giving, togetherness, and dedication like I do from the people at this organization. This led me to being a board member of Breakthrough T1D International (headquartered in the United States), and now I am currently the Vice-Chair of Breakthrough T1D International.

This journey can be credited in so many ways to Peter, who was, is, and always will be my north star.

Coast to Coast for Cures map of Canada

How did you devise the idea for Coast to Coast for Cures?

Matt Varey: As I retired in the summer of 2024, I thought about something my mum always taught me: “Never stop moving and never let the old man in.” So, with mentors like my mum telling me to “keep moving” and Peter Oliver saying, “Make sure it’s big, make sure it stands out, and make sure it challenges you,” I came up with the idea for the event.

Riding across Canada for 57 days and 7,500 km coast to coast for a cause is doing something different, and honestly, it scares me, which is good. I also love Canada so much, so that’s part of my journey, too. And I knew RBC would always have my back. As a mission, values-based organization, they told me in my retirement that if I ever did anything for Breakthrough T1D, they would be involved and support me 100%.

I want to challenge myself and hold true to my mum and Peter. My wife said she would take two months off work, bring the dog, and drive behind me. My wife is my everything, and I could never do this without her.

And one evening I made a public proclamation that I was going to do this, and then there was no turning back.

What are you most excited about for the ride, both personally and for raising awareness of Breakthrough T1D and type 1 diabetes?

Matt Varey: The world is changed by your actions, not by your words. Human beings, deep inside, want to see people accomplish something that is hard but shows dedication. I think that it attracts human beings to be generous. If we’re going to be asking people to help us raise half a million dollars, they want to see your skin in the game.

I’m excited about seeing the generosity of people. I’m an optimist; I always believe tomorrow is going to be better than today. I’m excited to see Canada for two months with my wife and see my former RBC colleagues, whom I miss dearly.

Do you have a message for the Breakthrough T1D community?

Matt Varey: We will never ever stop moving forward for cures. Ever. And I am just one of thousands and thousands of incredibly dedicated volunteers who also wake up every day and say the same thing, with even more credibility than myself.

As Mary Tyler Moore, who lived with T1D herself, would say, “You can’t be brave if you’ve only had easy things happen to you.” And people who live with T1D are brave every day. So please know that my commitment to you is also to be brave. And we will never ever stop until we get to a world free from type 1 diabetes.

Editor’s note: This interview is an abbreviated version of one previously published by Breakthrough T1D Canada. Read the full interview here.

After months of unexplainable symptoms, Katie Howell was diagnosed with type 1 diabetes (T1D) last year at age 25. Read on to learn more about how she confronted her new reality and became the first participant in New York City to enroll in the DIAGNODE-3 clinical trial.

The unexpected diagnosis

Katie hangin’ out in NYC.

Katie Howell, a Mississippian-turned-New Yorker, has a wide array of hobbies: crafting pottery at her local ceramics studio, enjoying old movies in the theater, cozying up with a book in Prospect Park, and taking in the sun at Rockaway Beach. Katie moved to Brooklyn after completing a Master of Public Administration degree at the University of Tennessee, Chattanooga, and she’s thoroughly enjoying getting to know her new neighborhood.

Suddenly, things took a turn. Last year, Katie started experiencing symptoms of something unknown—for three months, she had no idea what was going on with her body. Then, in a moment of complete shock, 25-year-old Katie was diagnosed with type 1 diabetes (T1D). “Without a family history of T1D and without any health issues of my own, being diagnosed with a sudden, serious chronic illness could not have been more unexpected,” Katie explained.

At the time of her diagnosis, Katie was confronted with a flood of emotions. There was not a single person in her life that had T1D or could understand her experience. “…one of the most challenging parts of being diagnosed with a chronic illness is accepting it […]. This comes with a lot of hopeless feelings, and it is tough to surrender control to an incurable, pervasive, and expensive health condition,” Katie lamented.

Feeling alone and lost, she had no choice but to accept that she was dealing with a major life change—whatever that meant for the future.

Influenced

It wasn’t long before Katie took to social media to learn more about her diagnosis and connect with the T1D community. On Instagram, she stumbled upon Lauren Bongiorno, a T1D influencer. Ms. Bongiorno posted a video promoting DIAGNODE-3, a phase 3 clinical trial for the disease-modifying therapy Diamyd® for early-stage T1D.


Check out Lauren on Instagram: @lauren_bongiorno

Katie found that DIAGNODE-3 was enrolling at The Pediatric Diabetes Center at Hassenfeld Children’s Hospital at NYU Langone. After reaching out to the team at NYU, she realized that the stars had aligned: they had just opened enrollment, and after completing the necessary screening, Katie would be Participant Number One.

“It gets easier every visit!”

Katie received her first study injection in January and will get her third and final injection this month, followed by routine check-ins. This includes blood work, physical exams, and mixed-meal tolerance tests to measure her body’s ability to produce insulin.

As per the study protocol, Katie doesn’t know if she’s receiving the placebo or the study drug, Diamyd®. Still, she likes being in the study: she’s made meaningful connections with the trial team, has learned a lot about T1D, and feels that she’s making a difference—not just for herself, but also for biomedical research.

Katie’s biggest hurdles? Bloodwork and hospitals. “One challenge of this study is the routine blood work and being treated at the hospital. However, it does feel like exposure therapy. It gets easier every visit!” she exclaimed.

Finding her community

Since her diagnosis, Katie has made lasting relationships with others in the T1D community. She connected with the Greater New York Metro Chapter of Breakthrough T1D after volunteering at a Walk in NYC last fall. They introduced her to a group chat with other newly diagnosed young women, where they can ask questions, network, and learn from each other as they navigate their new realities.

Participate in clinical trials

Clinical trials are key to bringing medical advancements from the lab to the clinic. This wouldn’t be possible without brave people with T1D, like Katie, who volunteer to participate. These studies offer the potential for life-changing treatment and move the ball forward for the T1D community.

Use our Clinical Trials Matching Tool to find a trial near you. Connect with a Clinical Trial Education Volunteer in your area to learn more about trial participation and answer any questions you may have.

From March 19-22, the world’s leading type 1 diabetes (T1D) researchers—including Breakthrough T1D staff, funded researchers, and partners—gathered in Amsterdam, the Netherlands, for the 2025 Advanced Technologies and Treatments in Diabetes (ATTD) conference. There were dozens of presentations, symposiums, panels and more over the course of the conference, providing a snapshot of the current state of T1D research, management, treatment, and, most importantly, progress towards cures.

Here are a few of the highlights.

Cell therapies

Cell therapies, which place insulin-producing cells into people living with T1D, are a priority of Breakthrough T1D for a simple reason: they have the potential to cure T1D. ATTD covered where cell therapies are on their path toward becoming a reality.

Breakthrough T1D Vice President of Research, Esther Latres, Ph.D., chaired a session on beta cell therapies for T1D. In this session, several researchers funded by Breakthrough T1D, including Andrew Stewart, M.D. (Mount Sinai Icahn School of Medicine), Cristina Nostro, Ph.D. (University of Toronto), Matthias Hebrok, Ph.D. (Helmholtz Munich), and Anath Shalev, M.D. (University of Alabama at Birmingham), discussed their work and the different tactics each are taking.

For example, Dr. Stewart and Dr. Shalev are working on cell survival and regeneration towards identifying ways to protect and prevent the loss of the body’s own beta cells —whereas Dr. Hebrok and Dr. Nostro are working on adapting the immune system to accept and not reject manufactured islet cells after transplantation. Dr. Hebrok is using an elegant approach based on generating chimeric antigen receptor (CAR) T cells to create a localized immune-suppressive environment.

This session highlighted the multiple-shots-on-goal approach required to address the challenge of protecting beta cells from immune-mediated destruction, whether the islet cells are the body’s own that remain at early stages of the disease or are the manufactured islet cells transplanted at later stages.

The speakers at Vertex’s industry symposium emphasized the same key point: the burden of T1D is too high, even with current therapies. Cell therapies can transform how this disease is managed—but they need to be minimally invasive and scalable. (If that sounds familiar, it’s because that’s what Breakthrough T1D is working to create through Project ACT.)

Key Takeaways

The data we have from clinical trials in cell therapies are the case in point for why Breakthrough T1D is prioritizing their development. However, there is still a long way to go before there is a renewable source of manufactured islets. The good news is that there is a lot of momentum around cell therapies, thanks to companies like Vertex, Breakthrough T1D’s Project ACT, and numerous scientists and researchers pushing us closer to our goal.

Using personal experiences to measure the benefits of cell therapies

It is important to understand how a medication, device, or therapeutic procedure (i.e., islet cell transplant) affects the lived experiences of a person. To do this, medical professionals use Person-Reported Outcome and Experience Measures (PROMs and PREMs) to understand how a new therapy influences a person’s day-to-day experience. These assessments generally inquire about how a person with T1D receiving a new therapy feels (stress, anxiety, overall mood), their diabetes management (time spent thinking about or making decisions about the disease), their use of the treatment or device (convenience, effectiveness, intrusiveness), and their overall quality of life (sleep, family life, work, finances, etc.).

Led by Breakthrough T1D Vice President of Research, Esther Latres, Ph.D., and co-organizers from the Breakthrough T1D Advocacy and Medical Affairs teams, Breakthrough T1D organized a PROMs workshop in Cell Therapy to capture meaningful data on a person’s subjective outcomes and experiences. The participants had a diverse range of expertise across the spectrum of T1D management, including people with lived T1D experience and professional and clinical research backgrounds. The one-day workshop focused on identifying what matter most to people living with T1D to inform PROMs assessments. The goal is to ensure that emerging cell therapy treatments and technologies are valued for both improving glycemic outcomes and improving lives.

Key Takeaways

Understanding the lived experience of people with T1D who receive novel cell therapies will be critical to assess what kind of impact they are having on a personal level. People living with T1D and T1D professionals gathered to discuss which factors matter most to people with T1D so the medical community can ask the right questions to those who receive new therapies.

Improving lives

Until we have cures, we need better tools for the millions around the globe living with T1D to lead healthier, fuller lives. That’s the focus of Breakthrough T1D’s Improving Lives portfolio.

Breakthrough T1D Chief Scientific Officer, Sanjoy Dutta, Ph.D., chaired a session on fully closing the loop with automated insulin delivery (AID) systems. (This means systems that require no input from the user.) There are a number of strategies to work towards this, including dual-hormone pumps, DIY systems, and systems that use insulin alone.

Breakthrough T1D Research Director, Jonathan Rosen, Ph.D., moderated a session titled Futuristic Technologies to Improve Outcomes and Quality of Life in Type 1 Diabetes. This session featured some innovative device and drug-device combinations under development for T1D. This includes a miniaturized insulin pump, a CGM combined with a pump into one wearable device, infusion sets made with new materials to promote extended wear, and non-insulin glucose control therapies paired with AID systems to improve outcomes.

Breakthrough T1D Chief Medical Officer International, Thomas Danne, M.D., chaired a panel titled Time in Tight Range: A Crucial Goal or Unnecessary Burden?

Time in Tight Range, which is now referred to as Time in Normal Glycemia (TING), is defined as time spent in a narrower blood glucose range (70-140 mg/dl). To lower the risk of complications as much as possible, we need to help people with T1D get as close as they can to replicating the glycemic range of a person without T1D.

That’s a lofty goal—especially considering that today, with the tools we have, the majority are not spending enough time in a wider range (70-180 mg/dl). This shift towards TING will give people with T1D a better target to aim for and reinforce the notion that we need better tools.

Key Takeaways

AID systems are helping people with T1D achieve better outcomes, but we need more advanced tools to help people achieve tighter glycemic control. We are making progress towards fully closing the loop and utilizing new strategies, like additional drugs, to help people do better until there are cures.

Building consensus for continuous ketone monitoring

Developing continuous ketone monitoring (CKM) systems is one of the current priorities of Breakthrough T1D’s Improving Lives work. It’s important because diabetic ketoacidosis (DKA) remains a significant and dangerous risk for people with T1D. CKMs have the potential to prevent DKA by informing people when ketones are rising so they can take steps to mitigate it before it becomes a crisis.

Additionally, they have the potential to enable safe use of SGLT inhibitors, a class of drugs that has benefits for heart and kidney complications but comes with an increased risk of DKA.

Led by the Medical Affairs team and Chief Medical Officer International, Thomas Danne, M.D., Breakthrough T1D is spearheading the development of an international consensus guidance document around CKM.

These devices are coming, and the medical community needs to be prepared. They will be a first, and there are many things to work out before they’re ready. For example, when should CKMs alert the users? What actions should the users take when the alarms go off? How do we balance real-world use with clinical utility?

These guidelines—and the experts from around the world who attended the meeting—will cover that. Together, they’re working on a manuscript they expect to publish later in 2025.

Key Takeaways

CKMs have the potential to prevent DKA and may allow for the safe use of SGLT inhibitors. To enable safe and effective usage and adoption of CKMs, medical professionals are working together to publish consensus guidelines.

Early detection

In addition to chairing a panel titled Early Detection of Diabetes and Intervention Strategies to Prevent Complications, Breakthrough T1D Associate Vice President of Community Screening and Clinical Trial Education, Anastasia Albanese-O’Neill, Ph.D., also led a symposium that laid out Breakthrough T1D’ s vision for screening and early detection. This session outlined the many components that must be achieved to fully realize our vision of a world without T1D. For early detection of diabetes, that means that research must first provide evidence of the importance and benefits of screening—a task that has been achieved by all the Breakthrough T1D worldwide screening programs—and work closely with regulatory affairs, health policy, and medical affairs to move towards general population screening.

Key Takeaways

We know the benefits of screening and why it’s important to achieve cures. The next step is to increase awareness of these benefits so that more people get screened.

Up next: ADA

The next big meeting is the year’s largest: The American Diabetes Association Annual Scientific Sessions. This meeting will take place from June 20-23 in Chicago, Illinois—and we’ll be there to cover the latest and greatest.  

Did you know that women make up only 28% of the science, engineering, technology, and mathematics (STEM) workforce?

While we have made some progress closing the gender gap in STEM professions in past decades, there is still more work to be done. To support this effort, it’s critically important that we take time to recognize the incredible contributions that women in science are making every day—and all the hard work they’ve done to get there.

This Women’s History Month, Breakthrough T1D is highlighting the accomplishments of Kelsey Voss, Ph.D., a recently appointed Assistant Professor at the University of Virginia (UVA) School of Medicine and a recipient of Breakthrough T1D’s Advanced Postdoctoral Fellowship Award.

Flipping the script

Kelsey and her pup, Chai.

Kelsey’s story begins the same way many other young women’s stories have: she was encouraged to pursue a subject other than science. Maybe something less “hard.”

After a less-than-perfect score on a math exam in high school, Kelsey was pushed toward Liberal Arts and away from courses like Chemistry. Her response? Push back even harder. “…I went all-in on biomedical research after that because that’s what I thought was the most interesting,” she recalled.

From then on, her path became clear. Kelsey majored in Biology at the University of Mary Washington and had her first encounter with the world of biomedical research. The next stop was George Mason University, where Kelsey volunteered in a lab studying host-pathogen interactions. She gained valuable experience in experimental techniques and journal publications, eventually transitioning to and completing a master’s degree there—each day becoming a better scientist.

From trainee to Principal Investigator

All the while, Kelsey knew she wanted to be a Principal Investigator (PI) one day, calling the shots in her own lab. She continued her training and pursued a Ph.D. at the Uniformed Services University, working under Andrew Snow, Ph.D., studying T cells. The lab environment was engaging, fun, and productive. But, research is hard—the graduate program was notoriously difficult, and Kelsey faced unexpected results in her studies. Despite these challenges, Kelsey thrived. “The challenge is to not let failure become tied to your self-worth,” she explained. This is a tough lesson that all scientists eventually come to bear.

She found a mentor in Dr. Snow.

To finish her training, Kelsey picked up and moved to Nashville, TN, for a postdoctoral fellowship at Vanderbilt University Medical Center. Working under Jeff Rathmell, Ph.D., she studied how targeting iron metabolism in T cells can change their behavior in autoimmune diseases like lupus. Kelsey herself struggles with autoimmune disease as well as some of her friends, so the work had personal meaning.

Calling the shots

During her fellowship, Kelsey applied for Breakthrough T1D’s Advanced Postdoctoral Fellowship Award—and got it—to translate her research in lupus to type 1 diabetes (T1D).

“This is what I really appreciate about [Breakthrough T1D]…new people and new ideas may be riskier but also have the power to make a big impact,” she fondly recalls of Breakthrough T1D’s willingness to take a gamble on her career. And it certainly paid off: Kelsey went on to start her own lab at UVA.

In her new position, Kelsey is building on her postdoctoral work and using both mouse models and human samples to better understand how T cell metabolism is dysregulated in autoimmunity—“a puzzle that never ends.”

Kelsey finds her work rewarding in many ways: she loves being creative and solving problems. “…one of the best feelings in the world is being the first person to see an experimental result in real time. For those moments, you are the only person alive who knows that information,” she explained.

Kelsey’s dream job includes leading the next generation of scientists—including the young women who were told that they should pursue something else but followed their hearts instead.

“Let them know their voices are valued.”

As much of life goes, Kelsey’s personal experiences as a woman in science “had its ups and downs.” A major motivator was seeing other strong women in science flourishing. One such scientist, Polly Matzinger, Ph.D., unapologetically offered a new paradigm of immunology (the “danger theory”) that was in direct contrast to the currently accepted view. To Kelsey, she is an inspiration—someone who can stand up for what she believes in and fight for it.

For women, this is easier said than done. Even in friendly and casual environments, it can be difficult for women in STEM and other fields to speak up and offer their points of view.

“What stands out to me…as a woman in science is how a lot of young women need time to develop the confidence to voice their opinions. They tend to withhold their questions or comments at conferences, journal clubs, or class discussions more often compared to men,” Kelsey explained. “I would encourage the community to allow space for girls to speak up in group settings and let them know their voices are valued.”


“I think we should change the way we think about research, specifically, as more of a creative pursuit that fits well with imaginative personalities. The next step would be to normalize and destigmatize the idea of ‘failure’ when young women start to experiment in these fields.”

Kelsey Voss, Ph.D.


At Breakthrough T1D, our mission is to accelerate life-changing breakthroughs to cure, prevent, and treat type 1 diabetes (T1D) and its complications. As T1D doesn’t discriminate, we advocate for equitable healthcare for all whose lives are impacted by the disease, no matter who they are or where they live.

Fostering a community of culture and belonging is a priority. As such, during Black History Month, we recognize our Black friends, family, and colleagues who help advance our mission.

This month, we shine the spotlight on Cassandra Bazile, Ph.D., an accomplished scientist at Breakthrough T1D who champions community, mentorship, and inclusion in STEM (science, technology, engineering, and mathematics).

A budding scientist finds her garden

Cassandra Bazile, Ph.D., after receiving her doctorate degree

Cassandra’s journey to a career in science began at Morgan State University (MSU), a historically Black institution in Baltimore, Maryland. Thanks to the Research Initiative for Scientific Enhancement (RISE) Program, she was introduced to the world of biomedical research from early in her academic career. While completing her studies, she found unforgettable support and mentorship in her professors at MSU, who offered Cassandra guidance on the many career possibilities within STEM.

“Their guidance played a pivotal role in shaping my academic and professional journey, encouraging me to pursue research and further my education. Their support not only helped me navigate my own path but also inspired my dedication to mentoring and uplifting others from underrepresented backgrounds in STEM,” she explained.

On to bigger and better pastures

After completing her undergraduate degree and working as a research technician at the Massachusetts Institute of Technology, Cassandra pursued her Ph.D. in Microbiology and Immunology at the University of Miami Miller School of Medicine. There, she studied B cells—immune cells that make antibodies and contribute to the development of several autoimmune diseases, including Lupus and T1D.

Cassandra’s increasing passion for understanding autoimmune disease combined with first-hand experience having an older cousin with T1D led her to pursue her current position at Breakthrough T1D. Now, she applies her unique scientific skillset to accelerate therapies that prevent, halt, or reverse T1D. She also finds fulfillment in engaging with the T1D community and deepening her appreciation of what it’s like to live with the disease.

“One of the most rewarding aspects of my role…is interacting with the community and sharing updates on exciting research […]. These conversations…not only allow me to inform and inspire others but also offer critical insights into the unmet needs of those living with T1D,” Cassandra explained.

The garden is growing, but there are still some weeds

As a Black woman in a largely white, male-dominated field, Cassandra’s secret to success is finding a strong community and assembling a mentorship network. Since the moment Cassandra knew she wanted to be a scientist, she’s learned a lot—the ability to advocate for herself is paramount, as is helping others navigate their own paths. Building these supportive connections within her community and becoming a mentor herself has been instrumental in driving her career forward.

While the scientific community has made progress in increasing representation of members of the BIPOC (Black, Indigenous, and People of Color) community, more work needs to be done. Culminating from her experiences, Cassandra suggests greater access to opportunities and mentorship in addition to fostering inclusive work environments.



At Breakthrough T1D, thanks to excellent scientists like Cassandra, every day we drive toward cures for T1D and make life with the disease better for the people who face it. This can only be achieved with a true diversity of thought, which happens when the best and brightest minds, from all backgrounds, come together.

The leadership, staff, and volunteers of Breakthrough T1D mourn the tragic, sudden loss of five type 1 diabetes (T1D) champions on Friday, Nov. 1, 2024. 

That night, five people who were pillars of the Breakthrough T1D Ride community died in a tragic, single-car accident.

The group included two married couples and one single individual—all very close friends and veteran Breakthrough T1D Ride participants.

All five people were inside the vehicle at the time of the accident—no one was riding a bicycle at the time.

The greatest group of people you wish you didn’t need to know

Members of the Breakthrough T1D Ride community

Understandably, the tragedy sent shockwaves through the tight-knit Ride community, as well as the entire Breakthrough T1D organization.

Chris Eaton, a lead volunteer partner of Breakthrough T1D Ride and the Ride Advisory Council, knew all five people well. 

“It’s said, ‘Ride is the greatest group of people you wish you didn’t need to know.’ Our friends embodied that feeling of inclusion, hope, and a steadfast focus on getting to a cure,” said Chris. “They will be sorely missed by their family, friends, and the Ride community.”   

Jeff and Michelle Bauer

Jeff and Michelle Bauer were highly involved in Breakthrough T1D Ride—especially Michelle.

“The Breakthrough T1D Ride program is a family, and Michelle exemplified this day in and day out,” said Anthony Geraci, National Director, Ride & Endurance.”  

Michelle had been a dedicated T1D advocate since her son, Jesse Alswager, was diagnosed with type 1 diabetes in 2000 at the age of 3. Tragically and unexpectedly, Jesse passed away at the age of 13 on February 3, 2010. 

After Jesse passed away, Michelle continued to advocate, educate, and push the envelope in his name. In honor of Jesse, the date he died—and generally all people who have passed away from T1D—Mile 23 of each Breakthrough T1D Ride is ridden in silence. 

“Whether it was riding thousands of miles in memory of her late son Jesse, authoring a book to help grieving families, bringing her husband Jeff Bauer into the Ride family, to joining the Ride Advisory Council, Michelle was all in,” added Anthony. 

In her spare time, Michelle had numerous other T1D-focused projects, including “Jesse Was Here,” which encompassed her work with other families around the world who had lost loved ones to T1D. 

Jeff proposed to Michelle in 2018 at Mile 23 of a Breakthrough T1D Ride.

The couple had a lake house in Crandon, Wisconsin, and spent a lot of time there. They were avid boaters.

Jeff and Michelle are survived by their blended family of five children—Alexander Bauer, Claudia Bauer, Samantha Alswager, Joseph Alswager and Sara Alswager—all of whom are now adults. 

Learn more about Jeff and Michelle and how to honor their lives.


“When I mentioned to Michelle off the cuff that I was thinking about completing my first Ironman, she was the first to offer up being my coach and cheerleader. The last text message I got from Michelle was on Wednesday of last week simply saying ‘Did you do it yet??’ That’s how I’ll remember Michelle. Always pushing people to be their best. Always pushing herself to be her best.”  

Anthony Geraci
National Director, Breakthrough T1D Ride and Endurance


Josh and Tammy Stahl

Josh and Tammy Stahl became close friends with the Bauers through the Ride program. They rode together most recently in La Crosse last August.

Josh started riding in 2011 for his and Tammy’s son, Gavin (now 17 years old) who lives with T1D. Josh had competed in 13 rides including, Lake Tahoe, La Crosse, and Death Valley. 

“I’ve been fortunate enough to talk to Josh and Tammy at rides for over a decade,” said Dan Woolf, Executive Director of Breakthrough T1D’s Wisconsin Chapter who has long been involved with Ride. “Most recently in La Crosse, where we traded stories of our spirit jerseys, kids, and what makes the Ride program special, which are the friends you make along the way.”

Josh and Tammy are survived by their sons Gavin Stahl and Blake Stahl.

Learn more about Josh and Tammy and how to honor their lives.


“The Stahls were the perfect example of that incredible spirit.They became close friends with so many people from all over the country while making such a difference for our Ride community, which is truly inspiring to me. It’s something that I’ll never forget and a testament to what wonderful people they were.”

Dan Woolf
Executive Director, Breakthrough T1D Wisconsin Chapter


Barry Sievers

Barry’s first Ride was 10 years ago. He had completed five rides including La Crosse, Nashville, and Loveland.

While he had no direct T1D connection, he was always willing to help with a smile. He hosted training rides at his house and even helped transport bikes with his trailer.  

“Barry’s infectious smile and boundless energy embodied our Team Wisconsin spirit,” wrote Joe Brady and Scott Hagen in a statement they issued together. 

Joe lives with T1D and is a veteran Ride coach. Scott is Barry’s best friend who recruited him for his first ride a decade ago.

Barry was the Senior Financial Manager for the Institute for Clinical and Translational Research at the University of Wisconsin—Madison.

Barry is survived by his adult son, David T. Sievers, and two school-age daughters, Emma Sievers and Addison Sievers.

Learn more about Barry and how to honor his life


“Whether opening his home for summer training rides, spinning tales on the team bus to Nashville, or cheering on the last rider at the Loveland finish line, Barry brought joy and camaraderie to every moment. Always ready with a solution to any bike issue, his ‘can do’ attitude inspired us all to push harder, fundraise better, and pedal faster toward our goals. Barry’s good-natured warmth and easy laughter will forever be cherished and missed.”

Statement from Joe Brady and Scott Hagen


Against many headwinds

“Greg Lemond, winner of the Tour de France, once said about cycling: ‘It doesn’t get easier, you just go faster,’” said Chris Eaton. 

“Against many headwinds, this group of friends led a community that embodies the imperative that we can, and will, cure type 1 diabetes despite the challenges. They will be missed.”


Sydney Yovic, Breakthrough T1D Chief Strategy Officer and Chief of Staff, dedicated the last 12 years to powering progress and advancing Breakthrough T1D’s mission. Having started as a project manager in the Research department, Sydney has led with inspiring passion and perseverance. Her legacy of meaningful and impactful contributions can be felt around the world.

Thankfully for Breakthrough T1D and the global T1D community, Sydney will continue driving us toward cures as the Chief Executive Officer of JDRF Australia, beginning in August. Before returning to her roots “down under,”  Sydney shares what fuels her passion for our mission, the breakthroughs she’s most proud of, and what she looks forward to in her new role. We wish Sydney much success and we look forward to her continued leadership as Breakthrough T1D leads the way to more effective solutions and cures for the global T1D community.

What drives your passion for Breakthrough T1D’s mission?

I’m driven by my love for my Uncle Jimmy, who was diagnosed with T1D when he was 30. He was a very important part of my young life, but he died from T1D complications at age 35. Losing him was devastating for my whole family. In the last 12 years, my passion has grown because of the thousands of amazing families I have grown to know and love who are impacted by T1D.

What stands out when you think about your career path from a Research project manager to Chief Strategy Officer and Chief of Staff?

I have had the incredible experience of working on many high impact projects over the years with inspiring colleagues and leaders. Thinking back, a few that stand out include:

What about your Breakthrough T1D experience was most rewarding?

I am passionate about our mission, I have always been intellectually curious, and intrinsically motivated by the need for constant improvement, so I have cherished every opportunity I’ve had to contribute to Breakthrough T1D moving faster toward cures. Traveling to Africa to see how our support is saving lives for the least fortunate people with T1D on the planet was one of my most rewarding experiences. And the people—from the staff who dedicate themselves day in and day out to advancing our mission, to our incredible Board of Directors, to the army of volunteers who will stop at nothing to support us, and our partner organizations and companies who work alongside us to cure T1D. I have had the good fortune of working alongside people who inspire me and have made me better over the years.

What does the future of Breakthrough T1D look like to you?

The future of Breakthrough T1D has never looked brighter. The science is promising, companies are committing billions of dollars on cures for T1D, and Breakthrough T1D is more focused than ever on putting the puzzle pieces together to advance our mission and cure this disease.

What are you most looking forward to in your new role as CEO of JDRF Australia?

I am most looking forward to working with the incredible team down in Australia to drive our collective mission forward. JDRF Australia has been a shining example of accelerating breakthroughs and impact for our community, led by the brilliant Mike Wilson. I look forward to building on the great organization JDRF Australia is today, and using my experience, relationships, and talents to create a velocity of impact for the T1D community both in Australia and around the globe.

JDRF Australia will become Breakthrough T1D Australia later this year.